By Dr. Ramon Velazquez Ph.D.
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Last updated: Mar 05, 20|
The world's smartest brain supplement.
Learn MoreDepending on where you live, buying legal nootropics can either be a walk in the park or a long wait at the pharmacy.
Some of the most frequently asked questions regarding nootropics and non-nootropic cognitive enhancers include:
And, most importantly:
Despite their massive rise in popularity, nootropic legality remains a contentious topic across the world – namely because no single government holds an identical legal definition of what constitutes a nootropic.<1>
In fact, most governments don't even recognize, and therefore regulate, nootropics. Leaving it almost entirely to the manufacturers and consumers to figure it out.
This, of course, comes with its pros and cons, and by no means do we intend to provide a comprehensive review on nootropic law within this guide.
But you should at least leave here with a better understanding on how to legally supplement nootropics for both recreational and professional uses.
Drug or Dietary Supplement? This is ultimately the question.
The nootropic users themselves – you and us – are "regulating" proper nootropic usage.
This is why DIY nootropic threads have recently become such a massive online forum phenomena.
Forum sites such as Reddit and Bluelight have become valuable resources nootropic safety, source, and usage concerns related to dosaging, stacking, cycling, fact-checking, etc. questions and answers.
Foods are legally assumed "innocent" (i.e., safe) until proven guilty, so to speak. This is a flipside to certain synthetics, which require for their legal innocence to be proven first.
In fact, this was the vision of Dr. Corneliu Giurgea, the founder of nootropics: To develop a series of cognitive enhancers absent of the "usual pharmacological effects of psychotropic drugs."<2>
Adherence to this criterion theoretically eliminates the need for law and regulation.
However, should a nootropic overstep this boundary, there are legal and policy measures in place to regulate its usage.
Is my nootropic legal?
To find our you need to know:
And then the sub-questions: How much control and which schedule?
The U.S. model provides the following definitions:
Typically, the schedule of a nootropic determines its control. High-risk substances are barred by strict access checkpoints.
Some are just flat-out illegal to own and consume. On the other hand, low-risk items are often sold OTC.
Due to their inherently safe, Dr. Giurgean design, most nootropics are low-risk, and therefore, legal.
There is no one-size-fits all legal definition of nootropics because there is no one-size-fits all nootropic.
Here's another turn of the screw: The particular legal status of a particular nootropic may not universally apply to other nation's regulatory codes.
For example, a single nootropic might be:
This is often the case with synthetic (e.g., racetams) and semi-synthetic (e.g., vinpocetine) nootropics.
For the sake of simplicity here, we'll provide a brief review on the common legal statuses of nootropics by their general types, including:
While bearing in mind that your local legal system may differ from the global law standard, rest assured that the first two categories on this list are virtually 100% legal across the world:
Sketch of the Ayurvedic adaptogen Bacopa monnieri.
Sketch of the Ayurvedic adaptogen Bacopa monnieri.
Bacopa monnieri, Rhodiola rosea, Camellia sinensis – such cognitive enhancing botanicals backed by centuries and centuries of safe, effective human use have generally received the "okay" by the world's top regulatory bodies.
And the same applies to their extracts as well – although not all, most notably:
Aside from a few rare examples, nootropic herbs and herbal extracts are completely legal to buy, own, and consume, even without the caveat that they be sold as research compounds.
Die-hard nootropic enthusiasts may even grow their herbal cognitive enhancers, if they are so inclined.
The legal accessibility of natural nootropics is earned by their legal and literal status as foods. Herbal extracts on the other hand don't quite literally qualify as foods however, so some user discretion may be advised in supplementing extracts.
Nootropic Herbs that Toe the Line: Since the legal downfall of ephedra, certain ephedra-like extracts (e.g., synephrine) have infiltrated the energy market. Despite their overwhelming popularity as fat-burners, natural, risky stimulants frequently dip into the nootropic scene as well.
Dietary compounds, such as vitamins, minerals, and aminos, are generally uninhibited by government regulation.
To completely restrict access to vitamins and minerals would require fatalistic restrictions on essentially all solid foods. Which would be a counter-productive move by health-focused agencies for obvious reasons.
As such, food-related nootropic nutrients require no regulation on the customer end of the transaction, yet there are purity, safety, and labeling codes that manufacturers must abide by to ensure the quality of their products.
Representing an annual expenditure of over $25 billion in the United States alone, dietary supplements undergo stringent quality assurance procedures before reaching the shelves.<6> For the customers, the legal concerns over nootropic vitamins and minerals are just that: Assurance.
However, to achieve brain-boosting performance, nootropic users will need to stack more than OTC vitamins and minerals in their supplement. Only the B vitamins possess substantial cognitive enhancing potential.
Huperzine-A, a Chinese club moss compound, straddles the line between organic and synthetic. By Jynto < CC0 >, via Wikimedia Commons
Nootropic Synthetics and Semi-Synthetics.Here is where you're most likely to encounter legal issues with nootropics:
If you're wondering what's the difference, here it is:
A key example of a synthetic nootropic – in fact the first synthesized nootropic – is piracetam, the original nootropic cognitive enhancer in a long series of cholinergic racetams.<7> To demonstrate the complexity of synthetic nootropic legality: piracetam is legal to order and consume in Canada and the USA, but is barred by prescription in the U.K. and scheduled in Australia – however, U.K. residents may freely purchase similar racetam variants, such as aniracetam and oxiracetam.
Semi-synthetic nootropics, such as vinpocetine and huperzine-A, greatly vary in their legality from country to country. This is because some countries view them as natural dietary supplements, others as controlled substances.
Nootropic Synthetics that Toe the Line: Nearly every synthetic and semi-synthetic nootropic toes the line somewhere in the world. Be sure to check local laws to clarify the legality of purchasing synthetic nootropics in your area.
Australia: For the most part, nootropic supplements are legal to purchase, own, and consume. Racetams are not OTC legal nootropics. Piracetam ranks as Schedule IV. Mind Lab Pro® ships here.
Canada: Canada designates Drug Identification Numbers (DIN) to regulated substances. Currently, there are no DINs for any popular nootropic supplements. Mind Lab Pro® ships here.
China: China houses the largest nootropic dispensary in the world and subjects its manufactured nootropics to high quality controls. Most nootropics are legal. However, Hong Kong has stricter substance limits. Mind Lab Pro® ships here.
France: Piracetam is a regulated substance, Ordonnance-Liste II. Most nootropics are legal. French nootropic regulation is light. Mind Lab Pro® ships here.
Germany: Germany is relatively strict when it comes to importing restricted nootropic substances from other countries, although most popular nootropics are unrestricted. Mind Lab Pro® ships here.
Japan: Japan also limits importation of restricted nootropic substances, an added frustration to Japan’s limited over-the-counter options — however, these options are reportedly expanding. Mind Lab Pro® ships here.
Russia: Russian nootropic legality is complex. Many legal nootropics including memory products may be bought over-the-counter, except for certain brand names which are inexplicably barred by prescription. Mind Lab Pro® ships here.
United Kingdom: Nootropics are generally legal to purchase, own and consume. Mind Lab Pro® ships here.
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United States: Finally, in USA it is legal to purchase, own, and consume all of the popular nootropic supplements. The U.S. does not control nor schedule most nootropics. The public can also buy some synthetics under the "research compounds" classification. Mind Lab Pro® ships here.
Mind Lab Pro® supplies the planet's safest, most research-backed nootropics.
As a result, all 11 Mind Lab Pro® ingredients support brain health.
And importantly, all are legal nootropics in virtually every country in the world:
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Generally speaking, Mind Lab Pro® nootropics qualify as safe and legal, free of banned substances and performance enhancers.
As such, Mind Lab Pro® may be taken as a legal performance enhancer by students, professionals, amateurs, athletes, and gamers.
More on Mind Lab Pro® nootropics
In other words, does Mind Lab Pro® ship to your country?
Odds are: Yes. Mind Lab Pro® ships to many countries.
However, if you are still unsure, here is a partial list of where Mind Lab Pro® delivers to:
United States, China, Japan, Germany, United Kingdom, France, Brazil, Italy, India, Russian Federation, Canada, Australia, South Korea, Spain, Mexico, Indonesia, Netherlands, Turkey, Saudi Arabia, Switzerland, Sweden, Nigeria, Poland, Argentina, Belgium, Norway, Austria, Thailand, United Arab Emirates, South Africa, Denmark, Malaysia, Singapore, Israel, Egypt, Hong Kong, Philippines, Finland, Chile, Ireland, Pakistan, Greece, Portugal, Iraq, Kazakhstan, Algeria, Qatar, Czech Republic, Peru, New Zealand, Romania, Vietnam, Bangladesh, Kuwait, Angola, Hungary, Ukraine, Morocco, Puerto Rico, Ecuador, Sri Lanka, Cuba, Belarus, Azerbaijan, Sudan, Luxembourg, Myanmar, Dominican Republic, Uzbekistan, Kenya, Guatemala, Uruguay, Croatia, Bulgaria, Ethiopia, Costa Rica, Slovenia, Tunisia, Lithuania, Tanzania, Turkmenistan, Panama, Lebanon, Serbia, Latvia, Cyprus, Paraguay, Iceland, Jamaica, Bahamas, and many other countries.
To learn more on Mind Lab Pro® safety and legality, read the Mind Lab Pro® FAQ page.
Posted on the World Anti-Doping Agency (WADA) website, the 2017 List of Prohibited Substances and Methods details a few banned nootropics for competitive sport.
WADA's illegal nootropics list includes the strongest and harshest stimulants and productivity boosters such as modafinil, adrafinil, phenylpiracetam and selegiline. However, the banned list includes non-nootropic performance enhancers as well, e.g., DHEA.
For athletes competing in traditional sports, this is old news. But for professional eSports gamers, legal mental enhancing gaming substances concerns are new. Therefore, it is always smart to check with WADA and local league standards to confirm eSport PED ethics code. Because you never know.
In conclusion, the mass majority of natural nootropics, as well as the semi-synthetics, are legal and freely accessible to buy, possess, and consume.
Buying pre-made manufactured nootropic supplements as stacks is the ultimate way to go to remove any nootropic legality concerns. Especially with Mind Lab Pro®.
CDP-Choline (Citicoline) and Alpha-GPC (L-alpha glycerylphosphorylcholine) are two popular nootropic supplements known for their cognitive enhancing effects. Both substances are known for their ability to improve memory, focus, and overall cognitive performance. However, despite their similarities, there are some key differences between the two substances.
In this article, we'll take a closer look at the benefits of each nootropic and compare their effectiveness, side effects, and price. Answering the question CDP-Choline vs Alpha-GPC: Which Nootropic is Best for Cognitive Enhancement?
What is Alpha-GPC?
Alpha-GPC, or alpha-glycerophosphocholine, is a natural compound found in the brain and in some food sources, such as dairy products and organ meats. It is involved in the synthesis of acetylcholine, an important neurotransmitter involved in memory and cognitive function. Alpha-GPC is thought to improve cognitive performance by increasing acetylcholine levels in the brain.
Benefits of Alpha-GPC:
Improves memory and cognitive performance: Alpha-GPC has been shown to improve cognitive function in individuals with cognitive impairment, as well as healthy individuals. In a study published in the Journal of the International Society of Sports Nutrition, Alpha-GPC was found to improve reaction time and cognitive function in healthy college-aged males.
Enhances focus and attention: Alpha-GPC has been shown to increase attention and focus in individuals with cognitive impairment. In a study published in the Journal of Alzheimer's Disease, Alpha-GPC was found to improve attention and cognitive function in individuals with Alzheimer's disease.
Increases energy levels: Alpha-GPC has been shown to increase energy levels and reduce fatigue in individuals. In a study published in the Journal of the International Society of Sports Nutrition, Alpha-GPC was found to improve power output and reduce fatigue in healthy individuals during a high-intensity exercise protocol.
Promotes muscle growth and recovery: Alpha-GPC has been shown to increase growth hormone levels, which can promote muscle growth and recovery. In a study published in the Journal of the International Society of Sports Nutrition, Alpha-GPC was found to increase growth hormone levels in healthy individuals during a resistance training program.
What is CDP-Choline?
CDP-choline, or citicoline, is a naturally occurring compound found in the brain and in small amounts in some food sources, such as eggs and liver. It is involved in the synthesis of phospholipids, which are essential components of cell membranes, and is also a precursor to the neurotransmitter acetylcholine. Citicoline is thought to improve cognitive function by increasing the availability of choline and cytidine, which are used in the synthesis of phospholipids and nucleic acids, respectively.
Benefits of CDP-Choline:
Improves memory and cognitive performance: CDP-Choline has been shown to improve memory and cognitive performance in healthy individuals and those with cognitive impairment. In a study published in the Journal of Alzheimer's Disease, CDP-Choline was found to improve memory and cognitive function in individuals with Alzheimer's disease.
Enhances focus and attention: CDP-Choline has been shown to improve attention and focus in healthy individuals. In a study published in the Journal of Psychopharmacology, CDP-Choline was found to improve attention and cognitive performance in healthy individuals.
Increases energy levels: CDP-Choline has been shown to increase energy levels and reduce fatigue in healthy individuals. In a study published in the Journal of International Society of Sports Nutrition, CDP-Choline was found to improve cognitive function and reduce fatigue in healthy individuals during a high-intensity exercise protocol.
Promotes neuroregeneration and neuroprotection: CDP-Choline has been shown to promote neuroregeneration and neuroprotection in individuals with traumatic brain injury (TBI) and those with cognitive impairment. In a study published in the Journal of Neurotrauma, CDP-Choline was found to promote neuroregeneration and improve cognitive function in individuals with TBI.
Overall, both Alpha-GPC and CDP-Choline have been shown to have cognitive enhancing effects, but CDP-Choline has the added benefit of promoting neuroregeneration and neuroprotection, especially in the context of TBI.
How They Work
Alpha-GPC works by increasing levels of the neurotransmitter acetylcholine in the brain. Acetylcholine is involved in various cognitive processes such as memory, attention, and learning. Alpha-GPC is a precursor to acetylcholine, meaning that it is used by the body to produce acetylcholine. By increasing levels of acetylcholine in the brain, Alpha-GPC may improve cognitive function and memory. It may also enhance focus and attention, as well as increase energy levels.
CDP-Choline works by increasing levels of choline and uridine in the brain. Choline is a nutrient that is involved in the production of the neurotransmitter acetylcholine, which is important for memory and cognitive function. Uridine is a nucleotide that is involved in the synthesis of phosphatidylcholine, a key component of cell membranes in the brain. By increasing levels of choline and uridine, CDP-Choline may enhance cognitive function and memory, as well as promote neuroregeneration and neuroprotection.
Both Alpha-GPC and CDP-Choline have been shown to have cognitive enhancing effects, but CDP-Choline has the added benefit of promoting neuroregeneration and neuroprotection, especially in the context of TBI. Studies have shown that CDP-Choline can increase levels of brain-derived neurotrophic factor (BDNF), a protein that plays a key role in the growth and survival of neurons. It has also been shown to have neuroprotective effects by reducing oxidative stress and inflammation in the brain.
In a study published in the Journal of Neurochemistry, CDP-Choline was found to protect against oxidative stress and improve cognitive function in rats with TBI. In another study published in the Journal of Alzheimer's Disease, CDP-Choline was found to improve memory and cognitive function in individuals with Alzheimer's disease.
Overall, both Alpha-GPC and CDP-Choline work by increasing levels of neurotransmitters and nutrients involved in cognitive function, but CDP-Choline has the added benefit of promoting neuroregeneration and neuroprotection.
CDP-Choline vs Alpha-GPC: Effectiveness
While both CDP-Choline and Alpha-GPC are effective nootropic supplements, studies have shown that CDP-Choline is more effective than Alpha-GPC. In a double-blind, randomized study, participants who took CDP-Choline showed significant improvements in attention, memory, and overall cognitive performance compared to those who took Alpha-GPC. Additionally, CDP-Choline has been shown to be more effective at increasing dopamine receptor densities in the brain, which can further enhance cognitive function.
CDP-Choline vs Alpha-GPC: Side Effects
Both CDP-Choline and Alpha-GPC are generally safe and well-tolerated by most people. However, some people may experience side effects, including headaches, gastrointestinal issues, and dizziness. Alpha-GPC has been known to cause insomnia and may increase blood pressure in some individuals. On the other hand, CDP-Choline has been shown to have a better safety profile, with fewer reported side effects.
CDP-Choline vs Alpha-GPC: Price
In terms of price, Alpha-GPC is generally less expensive than CDP-Choline. However, when comparing the two substances, it's important to consider their effectiveness and safety profile. While Alpha-GPC may be cheaper, it may not be as effective as CDP-Choline, and it may cause more side effects in some individuals.
Conclusion: Should you use CDP-Choline or Alpha-GPC?
When it comes to cognitive enhancement, CDP-Choline (Citicoline) is a better option than Alpha-GPC. Not only is it more effective at improving cognitive function, but it also has the added benefit of being neurogenerative and neuroprotective, especially in the context of traumatic brain injury (TBI) or neurogenesis and neuroprotection more generally. CDP-Choline has been extensively studied and has been shown to improve memory, attention, and overall cognitive performance in healthy individuals and those with cognitive disorders. It has also been shown to promote neuroregeneration and neuroprotection, making it an ideal choice for individuals looking to maintain and protect their cognitive function over time.
While Alpha-GPC is a useful nootropic supplement, it may not be as effective as CDP-Choline, and it may cause more side effects in some individuals. When considering the price of each supplement, it's important to weigh the potential benefits against the cost. In the case of CDP-Choline, the additional benefits of neuroregeneration and neuroprotection may make it a better long-term investment.
In conclusion, while both CDP-Choline and Alpha-GPC are effective nootropic supplements, CDP-Choline is the better choice for cognitive enhancement due to its superior effectiveness, safety profile, and neuroprotective properties. It's important to consult with a healthcare professional before starting any new supplement regimen, especially if you have any pre-existing medical conditions or are taking other medications.
Vyvamind uses Citicoline rather than Alpha-GPC or Choline bitartrate as its primary cholinergic for exactly these reasons as well as other ingredients like l tyrosine. Because Vyvamind seeks to act as a fast-acting study aid and a comprehensive cognitive enhancer, it exclusively uses nootropic ingredients that have been clinically proven to have meaningful effects on multiple measures of cognitive performance, mental energy and productivity.
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