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Emmelot, P. and Van Hoeven, R. P. Phospholipid unsaturation and plasma membrane organization. Chem Phys.Lipids ;14(3):236-246. View abstract.
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Gindin, J., Novikov, M., Kedar, D., Walter-Ginzburg, A., Naor, S., and Levi, S. The effect of plant phosphatidylserine on age-associated memory impairment and mood in the functioning elderly. Geriatric Institute for Education and Research and Dept of Geriatrics; Kaplan Hospital; Rehovot, Israel ;
Jager, R., Purpura, M., Geiss, K. R., Weiss, M., Baumeister, J., Amatulli, F., Schroder, L., and Herwegen, H. The effect of phosphatidylserine on golf performance. J Int Soc.Sports Nutr ;4(1):23. View abstract.
Kidd, P. M. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev ;1:70-84.
Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther ;12(4):315-322. View abstract.
Nerozzi, D., Aceti, F., Melia, E., Magnani, A., Marino, R., Genovesi, G., Amalfitano, M., Cozza, G., Murgiano, S., De, Giorgis G., and . [Phosphatidylserine and memory disorders in the aged]. Clin.Ter. 3-15-;120(5):399-404. View abstract.
Palmieri, G., Palmieri, R., Inzoli, MR Lombardi G., Sottini, C., Tavolato, B., and Giometto, B. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration. Clin Trials J ;24:73-83.
Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-;56(20):, -, . View abstract.
Ransmayr, G., Plorer, S., Gerstenbrand, F., and Bauer, G. Double-blind placebocontrolled trial of phosphatidylserine in elderly patients with arteriosclerotic encephalopathy. Clin Trials J ;24:62-72.
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Starks, M. A., Starks, S. L., Kingsley, M., Purpura, M., and Jager, R. The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc.Sports Nutr ;5:11. View abstract.
Vakhapova, V., Cohen, T., Richter, Y., Herzog, Y., and Korczyn, A. D. Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial. Dement.Geriatr Cogn Disord ;29(5):467-474. View abstract.
Villardita, J. C., Grioli, S., Salmeri, G., Nicoletti, F., and Pennisi, G. Multicenter clinical trial of brain phosphatidylserine in elderly patiens with intellectual deterioration. Clin Trials J ;24:84-93.
Amaducci L. Phosphatidylserine in the treatment of Alzheimer's disease: results of a multicenter study. Psychopharmacol Bull ;24:130-4.
Benton D, Donohoe RT, Sillance B, Nabb S. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci ;4:169-78. View abstract.
Blokland A, Honig W, Brouns F, Jolles J. Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS. Nutrition ;15:778-83. View abstract.
Bruton A, Nauman J, Hanes D, Gard M, Senders A. Phosphatidylserine for the treatment of pediatric attention-deficit/hyperactivity disorder: A systematic review and meta-analysis. J Altern Complement Med. ;27(4):312-322. View abstract.
Cenacchi T, Bertoldin T, Farina C, et al. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging (Milano) ;5:123-33. View abstract.
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Phosphatidylserine is a fatty substance called a phospholipid. It covers and protects the cells in your brain and carries messages between them.
Phosphatidylserine plays an important role in keeping your mind and memory sharp. Animal studies suggest that the level of this substance in the brain decreases with age.
Phosphatidylserine is taken to try to prevent memory loss and mental decline that may occur as you get older.
Several studies suggest that it may boost your brain power. People who took the supplement scored higher on short-term memory, mood, and concentration tests. For example, they could better recall names and objects. Much more research is needed to confirm these results.
Scientists have used phosphatidylserine in studies to treat symptoms of Alzheimer's disease. Again, there is not enough evidence that phosphatidylserine is of any help in treating this condition.
Phosphatidylserine has been suggested in the treatment of the following conditions, as well:
More research is needed before it can be recommended as a treatment for any of these conditions.
The supplement used in early studies was made from brain cells taken from cattle. Because of concerns about mad cow disease, an infectious disease that affects the brain tissue of cattle, scientists have developed a type of phosphatidylserine from plant sources such as soy or cabbage.
Many people can take the soy-derived supplement without any side effects. Research is still preliminary but it is likely safe up to 600 milligrams a day for no more than 10 days. Side effects are more common at doses of 300 milligrams and above. They may include:
However, optimal doses of phosphatidylserine have not been established for any condition. Quality and active ingredients in supplements may vary widely from maker to maker. This makes it very hard to establish a standard dose.
Phosphatidylserine can affect how certain medicines work in your body. Talk to your doctor before taking this supplement especially if you also take:
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