R. N. Rao and K. Chanda, Chem. Commun., , 58, 343 DOI: 10./D1CCK
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2-Aminopyridine is an organic compound with the formula H2NC5H4N. It is one of three isomeric aminopyridines. It is a colourless solid that is used in the production of the drugs piroxicam, sulfapyridine, tenoxicam, and tripelennamine. It is produced by the reaction of sodium amide with pyridine, the Chichibabin reaction.[3]
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Although 2-hydroxypyridine converts significantly to the pyridone tautomer, the related imine tautomer (HNC5H4NH) is less important for 2-aminopyridine.
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The acute toxicity is indicated by the LD50 = 200 mg/kg (rat, oral).
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